[HTML][HTML] Mitochondrial ceramide effects on the retinal pigment epithelium in diabetes

Y Levitsky, SS Hammer, KP Fisher, C Huang… - International Journal of …, 2020 - mdpi.com
Mitochondrial damage in the cells comprising inner (retinal endothelial cells) and outer
(retinal pigment epithelium (RPE)) blood–retinal barriers (BRB) is known to precede the …

[HTML][HTML] Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation

W Dai, WP Miller, AL Toro, AJ Black… - The FASEB …, 2018 - ncbi.nlm.nih.gov
The role of dyslipidemia in the development of retinal dysfunction remains poorly
understood. Using an animal model of diet-induced obesity/pre-type 2 diabetes, we …

[HTML][HTML] Young ossabaw pigs fed a western diet exhibit early signs of diabetic retinopathy

RR Lim, DAG Grant, TD Olver, J Padilla… - … & Visual Science, 2018 - iovs.arvojournals.org
Purpose: Recent clinical data suggest an increasing prevalence of obesity and type 2
diabetes in adolescents, placing them at high risk of developing diabetic retinopathy during …

miR-139-5p promotes neovascularization in diabetic retinopathy by regulating the phosphatase and tensin homolog

Z Zhang, C Song, T Wang, L Sun, L Qin, J Ju - Archives of Pharmacal …, 2021 - Springer
Pathological retinal neovascularization is a driver of the progression of diabetic retinopathy
(DR). The present study sought to identify the microRNAs (miRNAs) that are differentially …

Association between miRNAs expression and signaling pathways of oxidative stress in diabetic retinopathy

M Satari, E Aghadavod, M Mobini… - Journal of Cellular …, 2019 - Wiley Online Library
Diabetic retinopathy (DR) is a major cause of vision reduction in diabetic patients.
Hyperglycemia is a known instigator for the development of DR, even though the role of …

[HTML][HTML] Yiqi Tongluo Fang could preventive and delayed development and formation of diabetic retinopathy through antioxidant and anti-inflammatory effects

S Di, X An, B Pang, T Wang, H Wu, J Wang… - Biomedicine & …, 2022 - Elsevier
Abstract Background Yiqi Tongluo Fang (YQTLF) is an effective prescription for the treatment
of diabetic retinopathy (DR), but its mechanism of action remains unclear. Method The …

[HTML][HTML] Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids

L de Lemos, P Antas, IS Ferreira, IP Santos… - In vitro models, 2024 - Springer
Purpose Diabetic retinopathy (DR) is a complication of diabetes and a primary cause of
visual impairment amongst working-age individuals. DR is a degenerative condition in …

[HTML][HTML] Circulating biomarkers of inflammation and endothelial activation in diabetic retinopathy

F Storti, J Pulley, P Kuner, M Abt… - … vision science & …, 2021 - iovs.arvojournals.org
Inflammation and endothelial activation play a pivotal role in development and progression
of diabetic retinopathy (DR), a vision-threatening complication of diabetes mellitus (DM) and …

[HTML][HTML] Characterizations of hamster retina as a model for studies of retinal cholesterol homeostasis

N El-Darzi, N Mast, B Dailey, J Denker, Y Li, J Vance… - Biology, 2021 - mdpi.com
Simple Summary This work represents a comprehensive evaluation of hamster retina by
state-of-the-art methodologies and provides evidence that hamsters may represent a better …

[HTML][HTML] Hyperlipidemia and lipid-lowering therapy in diabetic retinopathy (DR): A bibliometric study and visualization analysis in 1993–2023

H Tan, X Fu, Y Chen, Y Wang, D Chen - Heliyon, 2023 - cell.com
Background Diabetic retinopathy (DR) is a common complication in diabetic patients. DR is
also a neurodegenerative disease. Patients with hyperglycemia, hyperlipidemia, and …