Abstract Curcumin (diferuloylmethane), an orange‑yellow component of turmeric or curry
powder, is a polyphenol natural product isolated from the rhizome of Curcuma longa. For …

Hypoxia is one of the fundamental biological phenomena that are intricately associated with
the development and aggressiveness of a variety of solid tumors. Hypoxia-inducible factors …

The aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia-
inducible factor (HIF)-1β, plays a pivotal role in the adaptive responses to (micro-) …

Curcumin, the active ingredient of turmeric (curry spice), is believed to be associated with
reducing the incidence of breast cancers in Asian countries. Anti-cancer efficacy of curcumin …

Hypoxia is a big roadblock for cancer radiotherapy, in which the hypoxia-inducible factor
(HIF-1) creates a microenvironment and cancer cells' intrinsic signaling networks conferring …

The hypoxic condition is a common feature that negatively impacts the efficacy of radio-and
chemotherapy in solid tumors. Hypoxia-inducible factors (HIF-1, 2, 3) predominantly regulate …

Low levels of oxygen or hypoxia is often an obstacle in health, particularly in pathological
disorders like cancer. The main family of transcription factors responsible for cell survival …

The renin-angiotensin system (RAS) is a principal determinant of arterial blood pressure and
fluid and electrolyte balance. RAS component dysregulation was recently found in some …

Background: management of head and neck squamous cell carcinomas (HNSCC) include
anti-Epidermal Growth Factor Receptor (EGFR) antibodies and radiotherapy, but resistance …

Glioblastoma multiforme (GBM) is the most common and lethal form of brain cancer and
these tumors are highly resistant to chemo-and radiotherapy. Radioresistance is thought to …