CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Building on the pyrazolopyrimidine CK2 (casein kinase 2) inhibitor scaffold, we designed a
small targeted library. Through comprehensive evaluation of inhibitor selectivity, we …

Most cancer-related deaths among patients with solid tumors are caused by metastases.
Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer …

Compounds targeting the circadian clock have been identified as potential treatments for
clock-related diseases, including cancer. Our cell-based phenotypic screen revealed …

Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …

Melanoma is a relentless type of skin cancer which involves myriad signaling pathways
which regulate many cellular processes. This makes melanoma difficult to treat, especially …

There are some reported anticancer and antibacterial effects for embelin, although, it's poor
aqueous solubility and bioavailability are main hindrance to apply embelin in therapeutics …

Background: Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder
that causes arteriovenous malformations (AVMs). Mutations in the genes encoding Endoglin …