Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …

In vivo gene editing therapies offer the potential to treat the root causes of many genetic
diseases. Realizing the promise of therapeutic in vivo gene editing requires the ability to …

An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

Cells that were previously described as homogeneous are composed of subsets with distinct
transcriptional states. However, it remains unclear whether this cell heterogeneity influences …

Dominant missense pathogenic variants in cardiac myosin heavy chain cause hypertrophic
cardiomyopathy (HCM), a currently incurable disorder that increases risk for stroke, heart …

In humans, lipid nanoparticles (LNPs) have safely delivered therapeutic RNA to hepatocytes
after systemic administration and to antigen-presenting cells after intramuscular injection …

The tumor microenvironment (TME) is characterized by several immunosuppressive factors,
of which weak acidity and l-arginine (l-arg) deficiency are two common features. A weak …

Systemically delivered lipid nanoparticles are preferentially taken up by hepatocytes. This
hinders the development of effective, non-viral means of editing genes in tissues other than …

Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

A central goal of chemical and drug delivery sciences is to maximize the therapeutic efficacy
of a given drug at the lowest possible dose. Here, we report a generalizable strategy that …