High genetic diversity of carbapenem-resistant Acinetobacter baumannii isolates recovered in Nigerian hospitals in 2016 to 2020

EE Odih, AO Oaikhena, A Underwood… - Msphere, 2023 - Am Soc Microbiol
Acinetobacter baumannii causes difficult-to-treat infections mostly among
immunocompromised patients. Clinically relevant A. baumannii lineages and their …

[HTML][HTML] Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

K Becker, V Aranzana-Climent, S Cao, A Nilsson… - Clinical Microbiology …, 2021 - Elsevier
Objectives Novel therapeutics are urgently required for the treatment of carbapenem-
resistant Acinetobacter baumannii (CRAB) causing critical infections with high mortality …

[HTML][HTML] Emergence of high colistin resistance in carbapenem resistant Acinetobacter baumannii in Pakistan and its potential management through immunomodulatory effect of …

U Ahsan, F Mushtaq, S Saleem, A Malik… - Frontiers in …, 2022 - frontiersin.org
Carbapenem resistant Acinetobacter baumannii has emerged as one of the most difficult to
treat nosocomial bacterial infections in recent years. It was one of the major causes of …

[HTML][HTML] Clinical features and outcomes of monobacterial and polybacterial episodes of ventilator-associated pneumonia due to multidrug-resistant Acinetobacter …

D Adukauskiene, A Ciginskiene, A Adukauskaite… - Antibiotics, 2022 - mdpi.com
Multidrug-resistant A. baumannii (MDRAB) VAP has high morbidity and mortality, and the
rates are constantly increasing globally. Mono-and polybacterial MDRAB VAP might differ …

[HTML][HTML] Complementary supramolecular drug associates in perfecting the multidrug therapy against multidrug resistant bacteria

P Sahoo - Frontiers in Immunology, 2024 - frontiersin.org
The inappropriate and inconsistent use of antibiotics in combating multidrug-resistant
bacteria exacerbates their drug resistance through a few distinct pathways. Firstly, these …

[HTML][HTML] Appelmans protocol–A directed in vitro evolution enables induction and recombination of prophages with expanded host range

TN Vu, JR Clark, E Jang, R D'Souza, NA Pinto, S Yoo… - Virus Research, 2024 - Elsevier
Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) present
significant healthcare challenges due to limited treatment options. Bacteriophage (phage) …

Bacteriophage therapeutics to confront multidrug‐resistant Acinetobacter baumannii ‐ a global health menace

S Rai, A Kumar - Environmental microbiology reports, 2022 - Wiley Online Library
We have already entered the post‐antibiotic era as the outbreaks of numerous multidrug‐
resistant strains in the community as well as hospital‐acquired infections are ringing alarm …

Identification of thresholds in relationships between specific antibiotic use and carbapenem-resistant Acinetobacter baumannii (CRAb) incidence rates in hospitalized …

WA Hayajneh, S Al-Azzam, D Yusef… - Journal of …, 2021 - academic.oup.com
Background Antibiotic resistance is a major threat to public health worldwide. The
relationship between the intensity of antibiotic use and resistance might not be linear …

[HTML][HTML] A fresh pH-responsive imipenem-loaded nanocarrier against Acinetobacter baumannii with a synergetic effect

S Gui, X Li, M Feng, H Liu, L Huang… - Frontiers in Bioengineering …, 2023 - frontiersin.org
In recent years, the treatment of Acinetobacter baumannii infections has become a pressing
clinical challenge due to its increasing incidence and its serious pathogenic risk. The …

[HTML][HTML] Effects of amikacin, polymyxin-B, and sulbactam combination on the pharmacodynamic indices of mutant selection against multi-drug resistant Acinetobacter …

S Zhu, C Song, J Zhang, S Diao, TM Heinrichs… - Frontiers in …, 2022 - frontiersin.org
Amikacin and polymyxins as monotherapies are ineffective against multidrug-resistant
Acinetobacter baumannii at the clinical dose. When polymyxins, aminoglycosides, and …