Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

The extracellular matrix (ECM) is a critical regulator of neural network development and
plasticity. As neuronal circuits develop, the ECM stabilizes synaptic contacts, while its …

Although elevated activity of the tryptophan-degrading enzyme indoleamine 2, 3-
dioxygenase (IDO) has been proposed to mediate comorbid depression in inflammatory …

Diabetes causes metabolic and physiologic abnormalities in the retina, and these changes
suggest a role for inflammation in the development of diabetic retinopathy. These changes …

Stroke is a major cause of death and adult disability. However, therapeutic options remain
limited. Numerous pathways underlie acute responses of brain tissue to stroke. Early events …

The tetracycline antibiotics are known to be effective in the treatment of both infectious and
noninfectious disease conditions. The 16S rRNA binding mechanism currently held for the …

Resistance of Cutibacterium acnes to topical antibiotics historically used to treat acne
(topical erythromycin and clindamycin and, more recently, topical azithromycin and …

Spinal glial reaction and proinflammatory cytokine induction play an important role in the
development of chronic pain states after tissue and nerve injury. The present study …

This scoping review assessed the effect of anti-inflammatory medications in mental
disorders. A search in Medline and the Cochrane database focusing on randomised …

Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically
available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective …