Human mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …

Bone defects repair and regeneration by various causes such as tumor resection, trauma,
degeneration, etc. have always been a key issue in the clinics. As one of the few organs that …

Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

Clonal hematopoiesis of indeterminate potential (CHIP), also referred to as aging-related
clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature …

The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Summary N 6-methyladenosine (m 6 A) on mRNA plays critical roles in various cellular
processes. However, the landscape and dynamics of m 6 A modification in hematopoietic …

Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem
cell and multipotent progenitor (HSC/MPP) expansion within their native niche has impeded …

Inefficient knock-in of transgene cargos limits the potential of cell-based medicines. In this
study, we used a CRISPR nuclease that targets a site within an exon of an essential gene …

Cell and gene therapies using haematopoietic stem cells (HSCs) epitomize the
transformative potential of regenerative medicine. Recent clinical successes for gene …