Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
MALAT1, one of the few highly conserved nuclear long noncoding RNAs (lncRNAs), is
abundantly expressed in normal tissues. Previously, targeted inactivation and genetic …
abundantly expressed in normal tissues. Previously, targeted inactivation and genetic …
Differentiation of human induced pluripotent stem cells into erythroid cells
M Ebrahimi, M Forouzesh, S Raoufi, M Ramazii… - Stem Cell Research & …, 2020 - Springer
During the last years, several strategies have been made to obtain mature erythrocytes or
red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB …
red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB …
[HTML][HTML] Dentine sialophosphoprotein signal in dentineogenesis and dentine regeneration
Dentineogenesis starts on odontoblasts, which synthesise and secrete non-collagenous
proteins (NCPs) and collagen. When dentine is injured, dental pulp progenitors …
proteins (NCPs) and collagen. When dentine is injured, dental pulp progenitors …
HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells
J Yang, Y Liu, H Yin, S Xie, L Zhang, X Dong, H Ni… - EMBO …, 2023 - embopress.org
Hematopoietic stem and progenitor cells (HSPCs) are cells mainly present in the bone
marrow and capable of forming mature blood cells. However, the epigenetic mechanisms …
marrow and capable of forming mature blood cells. However, the epigenetic mechanisms …
Crosstalk between the hepatic and hematopoietic systems during embryonic development
F Soares-da-Silva, M Peixoto, A Cumano… - Frontiers in Cell and …, 2020 - frontiersin.org
Hematopoietic stem cells (HSCs) generated during embryonic development are able to
maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC …
maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC …
Physioxia improves the selectivity of hematopoietic stem cell expansion cultures
Hematopoietic stem cells (HSCs) are a rare type of hematopoietic cell that can entirely
reconstitute the blood and immune system after transplantation. Allogeneic HSC …
reconstitute the blood and immune system after transplantation. Allogeneic HSC …
[HTML][HTML] The Akt–mTOR network at the interface of hematopoietic stem cell homeostasis
F Wu, Z Chen, J Liu, Y Hou - Experimental Hematology, 2021 - Elsevier
Highlights•The Akt–mTOR network governs HSC homeostasis.•Akt–mTOR signaling
regulates quiescence and metabolism in HSCs.•Akt–mTOR inhibitors are promising agents …
regulates quiescence and metabolism in HSCs.•Akt–mTOR inhibitors are promising agents …
Recent advances in developmental hematopoiesis: diving deeper with new technologies
B Weijts, L Yvernogeau, C Robin - Frontiers in Immunology, 2021 - frontiersin.org
The journey of a hematopoietic stem cell (HSC) involves the passage through successive
anatomical sites where HSCs are in direct contact with their surrounding microenvironment …
anatomical sites where HSCs are in direct contact with their surrounding microenvironment …
Biophysical cues of bone marrow-inspired scaffolds regulate hematopoiesis of hematopoietic stem and progenitor cells
W Li, H Liang, Y Ao, B Tang, J Li, N Li, J Wang, Y Du - Biomaterials, 2023 - Elsevier
Hematopoietic stem cells (HSCs) are adult multipotential stem cells with the capacity to
differentiate into all blood cells and immune cells, which are essential for maintaining …
differentiate into all blood cells and immune cells, which are essential for maintaining …
Cytokine combinations for human blood stem cell expansion induce cell-type–and cytokine-specific signaling dynamics
How hematopoietic stem cells (HSCs) integrate signals from their environment to make fate
decisions remains incompletely understood. Current knowledge is based on either averages …
decisions remains incompletely understood. Current knowledge is based on either averages …