PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS‐STING‐Mediated Interferon Response

X Geng, C Zhang, M Li, J Wang, F Ji, H Feng… - Advanced …, 2022 - Wiley Online Library
The Plk1‐interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase
DNA bridges in mitosis along with a complex of DNA repair proteins. Previous studies show …

[HTML][HTML] Expanding hematopoietic stem cell ex vivo: recent advances and technical considerations

JA Rubio-Lara, KJ Igarashi, S Sood, A Johansson… - Experimental …, 2023 - Elsevier
Hematopoietic stem cells (HSCs) are the most primitive cell type in the hematopoietic
hierarchy, which are responsible for sustaining the lifelong production of mature blood and …

Hematopoietic stem and progenitors cells gene editing: Beyond blood disorders

V Buffa, JR Alvarez Vargas, A Galy… - Frontiers in Genome …, 2023 - frontiersin.org
Lessons learned from decades-long practice in the transplantation of hematopoietic stem
and progenitor cells (HSPCs) to treat severe inherited disorders or cancer, have set the …

Enzyme‐Photodynamic Adaptive Bionic Periosteum for Bone Revitalization

Y Chen, X Jin, J Lu, S Li, C Li, C Yu… - Advanced Functional …, 2024 - Wiley Online Library
The lack of periosteum in bone allografts is considered a major cause of bone graft failure;
however, the currently used artificial periosteum has failed to proactively adapt to its …

Exploring the potential of predicted miRNAs on the genes involved in the expansion of hematopoietic stem cells

M Elahimanesh, N Shokri, R Shabani, M Rahimi… - Scientific Reports, 2024 - nature.com
A major challenge in therapeutic approaches applying hematopoietic stem cells (HSCs) is
the cell quantity. The primary objective of this study was to predict the miRNAs and anti …

[HTML][HTML] CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells

E Somuncular, J Hauenstein, P Khalkar… - Stem Cell Reports, 2022 - cell.com
Hematopoiesis is maintained by functionally diverse lineage-biased hematopoietic stem
cells (HSCs). The functional significance of HSC heterogeneity and the regulatory …

Enhanced Cellular Uptake through Nanotopography‐Induced Macropinocytosis

M Aramesh, D Yu, M Essand… - Advanced Functional …, 2024 - Wiley Online Library
Efficient cellular uptake of biomolecules, including genetic material, mRNA, proteins, and
nanoparticles, requires novel approaches to overcome inherent cellular barriers. Here, the …

BML‐260 promotes the growth of cord blood and mobilized peripheral blood hematopoietic stem and progenitor cells with improved reconstitution ability

E Albayrak, S Akgol, RD Turan, M Uslu… - Journal of Cellular …, 2022 - Wiley Online Library
Hematopoietic stem cells (HSCs), which are multipotent and have the ability to self‐renew,
are frequently used in the treatment of hematological diseases and cancer. Small molecules …

Bone marrow-derived mononuclear stem cells in the treatment of retinal degenerations

D García-Ayuso, J Di Pierdomenico… - Neural Regeneration …, 2022 - journals.lww.com
Retinal degenerative diseases affecting the outer retina in its many forms (inherited,
acquired or induced) are characterized by photoreceptor loss, and represent currently a …

Combating bone marrow failure with polymer materials

KC Koch, N Jadon, I Thesmar, GN Tew… - Frontiers in …, 2024 - frontiersin.org
Bone marrow failure (BMF) has become one of the most studied autoimmune disorders,
particularly due to its prevalence both as an inherited disease, but also as a result of …