Haematopoiesis within the bone marrow (BM) represents a complex and dynamic process
intricately regulated by neural signaling pathways. This delicate orchestration is susceptible …

Hematopoietic stem/progenitor cells (HSPCs) are supported and regulated by niche cells in
the bone marrow with an important characterization of physiological hypoxia. However, how …

Hematopoietic stem cells (HSCs) manifest impaired recovery and self-renewal with a
concomitant increase in differentiation when exposed to ambient air as opposed to …

Evaluating the epigenetic landscape in the stem cell compartment at the single-cell level is
essential to assess the cells' heterogeneity and predict their fate. Here, using a genome …

The behavior of somatic stem cells is regulated by their niche. Interaction between
hematopoietic stem cells (HSCs) and their niches are a representative model to understand …

Highlights•Recent developments in bone marrow failure research are explored.•Distinct
mechanisms of clonal evolution and implications for surveillance for patients affected with …

Gene editing using engineered nucleases frequently produces on-and off-target indels in
hematopoietic stem cells (HSCs). Gene-edited HSC cultures thus contain genetically …

Profound malnutrition and immunodeficiency are serious negative effects of radiotherapy
and bone marrow transplantation for hematologic malignancy patients. This study aimed to …

The widespread clinical application of cord blood (CB) for hematopoietic stem cell (HSC)
transplantation is limited mainly by the inadequate number of hematopoietic stem and …

The bone marrow is the main site of blood cell production in adults, however, rare pools of
hematopoietic stem and progenitor cells with self-renewal and differentiation potential have …