The endoplasmic reticulum (ER) is the largest intracellular organelle. It forms a complex
network of continuous sheets and tubules, extending from the nuclear envelope (NE) to the …

Apoptosis is characterized by the destruction of essential cell organelles, including the cell
nucleus. The nuclear envelope (NE) separates the nuclear interior from the cytosol. During …

The nuclear lamina is a key structural element of the metazoan nucleus. However, the
structural organization of the major proteins composing the lamina is poorly defined. Using …

ATR responds to mechanical stress at the nuclear envelope and mediates envelope-
associated repair of aberrant topological DNA states. By combining microscopy, electron …

Fascin is an F-actin-bundling protein shown to stabilize filopodia and regulate adhesion
dynamics in migrating cells, and its expression is correlated with poor prognosis and …

We present an in‐depth analysis of selected CASP15 targets, focusing on their biological
and functional significance. The authors of the structures identify and discuss key protein …

Nuclear mechanotransduction has been implicated in the control of chromatin organization;
however, its impact on functional contractile myofibers is unclear. We found that deleting …

Microgravity and space radiation (SR) are two highly influential factors affecting humans in
space flight (SF). Many health problems reported by astronauts derive from endothelial …

Most DNA viruses replicate in the nucleus and exit it either by passing through the nuclear
pores or by rupturing the nuclear envelope. Unusually, herpesviruses have evolved a …

The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces
during cell migration, differentiation, and various diseases. The function of LINC complexes …