[HTML][HTML] Phytotherapeutic applications of alkaloids in treating breast cancer

S Rampogu, T Balasubramaniyam, JH Lee - Biomedicine & …, 2022 - Elsevier
Breast cancer is one of the major causes of mortality in women worldwide. The current
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …

[HTML][HTML] Flavonoids and saponins: What have we got or missed?

X Wang, Y Ma, Q Xu, AN Shikov, ON Pozharitskaya… - Phytomedicine, 2023 - Elsevier
Background Flavonoids and saponins are important bioactive compounds that have
attracted wide research interests. This review aims to summarise the state of the art of the …

A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast

G Naseri - Nature Communications, 2023 - nature.com
Secondary natural products (NPs) are a rich source for drug discovery. However, the low
abundance of NPs makes their extraction from nature inefficient, while chemical synthesis is …

Extraction of bioactive compounds from Dipsacus fullonum leaves using deep eutectic solvents

P Saar-Reismaa, M Koel, R Tarto, M Vaher - Journal of Chromatography A, 2022 - Elsevier
In this study, deep eutectic solvent (DES) based systems were evaluated for selective
extraction and optimized for increased recovery of chlorogenic acid derivatives, flavone …

Asymmetric Synthesis of Fused-Ring Tetrahydroisoquinolines and Tetrahydro-β-carbolines from 2-Arylethylamines via a Chemoenzymatic Approach

L Yang, J Li, Z Xu, P Yao, Q Wu, D Zhu, Y Ma - Organic Letters, 2022 - ACS Publications
While chiral fused-ring tetrahydroisoquinoline (THIQ) and tetrahydro-β-carboline (THβC)
scaffolds have attracted considerable interest due to their wide spectrum of biological …

Selective and Functional-Group-Tolerant Photoalkylation of Imines by Energy-Transfer Photocatalysis

SK Ghosh, L He, Z Tang, RJ Comito - The Journal of Organic …, 2023 - ACS Publications
Basic amines show broad bioactivity and remain a promising source of new medicines. The
direct photoalkylation of imines offers a promising strategy for complex amines. However …

[HTML][HTML] Antiparasitic potential of asteraceae plants: A comprehensive review on therapeutic and mechanistic aspects for biocompatible drug discovery

C Kamaraj, C Ragavendran, RCS Kumar, A Ali… - Phytomedicine Plus, 2022 - Elsevier
Background Medicinal herbs are used to cure parasitic protozoan diseases. Protozoan
parasites continue difficult to treat, but diverse extracts from both terrestrial and aquatic …

A mini review on human serum albumin-natural alkaloids interaction and its role as drug carrier

T Ghosh, K Bhadra - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Human serum albumin (HSA) is one of the main protein components of the circulatory
system. It's well characterized physiological role is to carry numerous ligands to their target …

Molecular hybridization of alkaloids using 1, 2, 3-triazole-based click chemistry

D Buchanan, AM Pham, SK Singh, SS Panda - Molecules, 2023 - mdpi.com
Alkaloids found in multiple species, known as 'driver species', are more likely to be included
in early-stage drug development due to their high biodiversity compared to rare alkaloids …

Alkaloids in future drug discovery

MJU Ferreira - Molecules, 2022 - mdpi.com
Alkaloids are nitrogen-containing compounds, biosynthesized by both marine and terrestrial
organisms, often with strong biological properties. They are among the largest classes of …