Malaria is one of the life‐threatening parasitic diseases that is endemic in tropical areas. The
increased prevalence of malaria due to drug resistance leads to a high incidence of …

Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …

Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and
present in various cells throughout the body. Its diverse physiological functions encompass …

In this work, we designed and synthesized 35 new triazolopyrimidine, pyrazolopyrimidine
and quinoline derivatives as P. falciparum inhibitors (3D7 strain). Thirty compounds …

Despite an unprecedented 2 decades of success, the combat against malaria—the mosquito-
transmitted disease caused by Plasmodium parasites—is no longer progressing. Efforts …

Malaria control relies heavily on the small number of existing antimalarial drugs. However,
recurring antimalarial drug resistance necessitates the continual generation of new …

" A book is like a garden carried in the pocket."–Chinese proverb This Chinese proverb
simply means: Reading helps strengthen one's intellect, which correlates with the feeling …

Metacytofilin (MCF) was isolated from the fungus Metarhizium sp. TA2759. Although MCF
possesses anti-Toxoplasma activity, the effects of this compound against other parasites are …

The increased prevalence of malaria requires continuous efforts towards the discovery of
natural antimalarial agents targeting important biochemical pathways of the parasite. The …

Due to an undecided target and the prescription of chiral-aminoquinolines (chloroquine,
primaquine and quinacrine) in the racemic form, the mechanism of action as well as the …