NMDA receptors in clinical neurology: excitatory times ahead
Since the N-methyl-D-aspartate receptor (NMDAR) subunits were cloned less than two
decades ago, a substantial amount of research has been invested into understanding their …
decades ago, a substantial amount of research has been invested into understanding their …
The glutamatergic dysfunction hypothesis for schizophrenia
JT Coyle - Harvard review of psychiatry, 1996 - Taylor & Francis
Schizophrenia is a syndrome, undoubtedly with multiple etiologies, that variably exhibits
several features including positive and negative symptoms, cognitive deficits, onset in young …
several features including positive and negative symptoms, cognitive deficits, onset in young …
The glutamatergic system and Alzheimer's disease: therapeutic implications
DA Butterfield, CB Pocernich - CNS drugs, 2003 - Springer
Alzheimer's disease affects nearly 5 million Americans currently and, as a result of the baby
boomer cohort, is predicted to affect 14 million Americans and 22 million persons totally …
boomer cohort, is predicted to affect 14 million Americans and 22 million persons totally …
[HTML][HTML] Involvement of cholinergic, adrenergic, and glutamatergic network modulation with cognitive dysfunction in Alzheimer's disease
Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …
Kynurenine metabolism in Alzheimer's disease
H Baran, K Jellinger, L Deecke - Journal of neural transmission, 1999 - Springer
L-kynurenine (L-KYN) serves as a substrate for the synthesis of neurotoxic 3-OH-kynurenine
(3-OH-KYN) and neuroprotective kynurenic acid (KYNA). KYNA is able to interact with …
(3-OH-KYN) and neuroprotective kynurenic acid (KYNA). KYNA is able to interact with …
Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia.
Objective The authors conducted a dose-finding study of D-cycloserine, a partial agonist at
the glycine site of the N-methyl-D-aspartate subtype of the glutamate receptor, added to …
the glycine site of the N-methyl-D-aspartate subtype of the glutamate receptor, added to …
Glutamate signaling in the pathophysiology and therapy of schizophrenia
Glutamatergic neurotransmission, particularly through the N-methyl-d-aspartate (NMDA)
receptor, has drawn attention for its role in the pathophysiology of schizophrenia. This paper …
receptor, has drawn attention for its role in the pathophysiology of schizophrenia. This paper …
Benzoate, a D-amino acid oxidase inhibitor, for the treatment of early-phase Alzheimer disease: a randomized, double-blind, placebo-controlled trial
Background N-methyl-D-aspartate receptor (NMDAR)-mediated neurotransmission is vital
for learning and memory. Hypofunction of NMDAR has been reported to play a role in the …
for learning and memory. Hypofunction of NMDAR has been reported to play a role in the …
Modulation of learning processes by ionotropic glutamate receptor ligands
W Danysz, W Zajaczkowski… - Behavioural …, 1995 - journals.lww.com
A great body of evidence has been provided for the role of N-methyl-D-aspartate (NMDA)
receptors in learning processes, since the pioneering work of Morris el al.(1986) showing …
receptors in learning processes, since the pioneering work of Morris el al.(1986) showing …
Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment
GE Tsai, WE Falk, J Gunther… - American journal of …, 1999 - Am Psychiatric Assoc
OBJECTIVE: Glutamatergic neurotransmission is important for memory and cognition and is
severely affected in Alzheimer's disease. d-Cycloserine exhibits partial agonist activity at the …
severely affected in Alzheimer's disease. d-Cycloserine exhibits partial agonist activity at the …