The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

A series of 12 S‐substituted tetrahydrobenzothienopyrimidines were designed and
synthesized based on the donepezil scaffold. All the newly synthesized compounds were …

Ethnopharmacological relevance Natural products play a critical role in drug development
and is emerging as a potential source of biologically active metabolites for therapeutic …

Since multiple myeloma (MM) remains a cureless malignancy of plasma cells to date, it
becomes imperative to develop novel drugs and therapeutic targets for MM. We screened a …

Irradiation on N-(ω-alkenyl) isocarbostyrils in the presence of an iridium photocatalyst by
LEDs emitting 455 nm light gave the corresponding cyclobutane-fused benzo [b] quinolizine …

Neuronal injury and apoptosis are important causes of the occurrence and development of
many neurodegenerative diseases, such as cerebral ischemia, Alzheimer's disease, and …

Recent evidence suggests that misfolding, clumping, and accumulation of proteins in the
brain may be common causes and pathogenic mechanism for several neurological …

Difficult or even non-healing diabetic foot ulcers (DFU) are a global medical challenge.
Although current treatments such as debridement, offloading, and infection control have …

A robust, well-functioning immune system is the cornerstone of good health. Various factors
may influence the immune system's effectiveness, potentially leading to immune system …

Viruses are widely recognized as the primary cause of infectious diseases around the world.
The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to …