Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

In the past decade, relative proteomic quantification using isobaric labeling technology has
developed into a key tool for comparing the expression of proteins in biological samples …

Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to
secrete adequate levels of insulin. The molecular mechanisms underlying the progressive …

Abstract Type 2 diabetes (T2D) is a global health problem characterised by chronic
hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised …

Progressive decline of pancreatic beta cell function is central to the pathogenesis of type 2
diabetes. Protein phosphorylation regulates glucose-stimulated insulin secretion from beta …

Pancreatic β-cell dysfunction and insulin resistance are two of the major causes of type 2
diabetes (T2D). Recent clinical and experimental studies have suggested that the functional …

The ability of pancreatic β-cells to respond to increased demands for insulin during
metabolic stress critically depends on proper ribosome homeostasis and function. Excessive …

Ca 2+ is an essential signal for pancreatic β-cell function. Ca 2+ plays critical roles in
numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic …

Inflammatory bowel disease (IBD) has been referred to as the “green cancer,” and its
progression to colorectal cancer (CRC) poses a significant challenge for the medical …

Amyotrophic lateral sclerosis (ALS) involves the abnormal posttranslational modifications
and fibrillization of copper, zinc superoxide dismutase (SOD1) and TDP-43. However, how …