Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect
organisms against various noxious stimuli including DNA damage, oxidative stress …

Mitochondrial proteolysis is an evolutionarily conserved quality-control mechanism to
maintain proper mitochondrial integrity and function. However, the physiological relevance …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Individuals that maintain healthy skeletal tissue tend to live healthier, happier lives as proper
muscle function enables maintenance of independence and actuation of autonomy. The …

The mechanistic target of rapamycin complex 1 (mTORC1) kinase controls growth in
response to nutrients, including the amino acid leucine. In cultured cells, mTORC1 senses …

Beside inherited muscle diseases many catabolic conditions such as insulin resistance,
malnutrition, cancer growth, aging, infections, chronic inflammatory status, inactivity, obesity …

The muscle is the main edible part of the animal trunk. Previous studies have shown that
tryptophan is the limiting amino acid for protein synthesis. This study investigated whether …

Flesh quality is evaluated according to nutritional value and sensory quality.
Cinnamaldehyde (CIN) improves mammalian meat quality, but research relating this to …

Catabolic conditions, such as starvation, inactivity, and cancer cachexia, induce Forkhead
box O (FOXO) transcription factor (s) expression and severe muscle atrophy via the …

Sestrins are a family of proteins that respond to a variety of environmental stresses,
including genotoxic, oxidative, and nutritional stresses. Sestrins affect multiple signaling …