When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its
clinical significance, there are still significant gaps in our understanding of pathogenic and …

Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while
minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying …

Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity
and comprises primordial innate defense. Phagocytes mobilize interferon-inducible …

Type I Interferons (IFNs) are hallmark cytokines produced in immune responses to all
classes of pathogens. Type I IFNs can influence dendritic cell (DC) activation, maturation …

The continued threat of emerging, highly lethal infectious pathogens such as Middle East
respiratory syndrome coronavirus (MERS‐CoV) calls for the development of novel vaccine …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

Despite our knowledge of the protective role of antibodies passed to infants through breast
milk, our understanding of immunity transfer via maternal leukocytes is still limited. To …

Inflammasome activation is an innate host defense mechanism initiated upon sensing
pathogens or danger in the cytosol. Both autophagy and cell death are cell autonomous …

Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been
administered to humans. However, we lack a comprehensive understanding of the immune …