Regulatory T cells (Tregs) play a cardinal role in the immune system by suppressing
detrimental autoimmune responses, but their role in acute, chronic infectious diseases and …

Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune
cells. Despite the central role for microglia in neuroinflammation and neurodegeneration …

Hepatocellular carcinoma (HCC) is frequently associated with pathogen infection–induced
chronic inflammation. Large numbers of innate immune cells are present in HCCs and can …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic of severe coronavirus disease 2019 (COVID-19). Staphylococcus aureus is …

Summary Type I interferons (IFN-Is) are fundamental for antiviral immunity, but their role in
bacterial infections is contradictory and incompletely described. Streptococcus pyogenes …

IFNs are comprised of three families of cytokines that confer protection against pathogen
infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and …

Background: Depression is among the commonest of psychiatric disorders, and
inflammatory mechanisms have been suggested to play a role in its pathophysiology …

Tuberculosis causes∼ 1.5 million deaths every year, thus remaining a leading cause of
death from infectious diseases in the world. A growing body of evidence demonstrates that …

The presence of the endogenous Leishmania RNA virus 1 (LRV1) replicating stably within
some parasite species has been associated with the development of more severe forms of …

Abstract Type I IFNs (IFN-Is) play pivotal roles in host defense against viral infections but
remain enigmatic against bacterial pathogens. In this study, we recombinantly expressed …