Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair
host resistance to intracellular bacteria in mice. However, the precise role of type I IFN …

Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation
characterized by the influx of myeloid cells and production of proinflammatory cytokines …

The intestinal mucosa forms an active interface to the outside word, facilitating nutrient and
water uptake and at the same time acts as a barrier toward the highly colonized intestinal …

The human interferon α2 (IFNα2) was the first highly active IFN subtype to be cloned in the
early eighties. It was also the first IFN and the first cytokine to be produced and …

Mycobacterium abscessus complex (MAB) is a rapidly growing mycobacterium (RGM)
whose clinical significance as an emerging human pathogen has been increasing …

Hematopoiesis is a remarkable system that plays an important role in not only immune cell
function, but also in nutrient transport, hemostasis and wound healing among other …

Interferons (IFNs) are critical for immune defense against pathogens. While type‐I and‐III
IFNs have been reported to inhibit SARS‐CoV‐2 replication, the antiviral effect and …

Protozoan parasites, such as Plasmodium, Leishmania, Toxoplasma, Cryptosporidium, and
Trypanosoma, are causative agents of health-threatening diseases in both humans and …

Whereas type I interferons (IFNs-I) were proposed to be elevated in human periodontitis,
their role in the disease remains elusive. Using a bacterial-induced model of murine …

Effective recognition of viral infection and subsequent triggering of antiviral innate immune
responses are essential for the host antiviral defense, which is tightly regulated by multiple …