Autophagy can mediate antiviral immunity. However, it remains unknown whether
autophagy regulates the immune response of dendritic cells (DCs) to influenza A (H1N1) …

Vesicular stomatitis virus (VSV)(a rhabdovirus) and its variant VSV-ΔM51 are widely used
model systems to study mechanisms of virus-host interactions. Here, we investigated how …

Diabetic retinopathy (DR) is one of the major causes of visual impairment and irreversible
blindness in developed regions. Aside from abnormal angiogenesis, inflammation is the …

The gastrointestinal epithelium guides the immune system to differentiate between
commensal and pathogenic microbiota, which relies on intimate links with the type I IFN …

Immunization with attenuated whole Plasmodium sporozoites constitutes a promising
vaccination strategy. Compared to replication-deficient parasites, immunization with …

Humanity has regularly faced the threat of epidemics and pandemics over the course of
history. Successful attempts to protect populations were initially made with the development …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) leading to demyelination and axonal damage. It often affects young adults and can …

Background Infectious diseases are still a leading cause of death and, with the emergence
of drug resistance, pose a great threat to human health. New drugs and strategies are thus …

Viral infection or lipopolysaccharide (LPS) treatment induces expression of a large array of
genes, the products of which play a critical role in host antipathogen immunity and …

The type I IFNs activate an array of signaling pathways, which are initiated after IFNs bind
their cognate receptors, IFNα/β receptor (IFNAR) 1 and IFNAR2. These signals contribute to …