Nanobiotechnology in neurodegenerative diseases

J Jampílek, K Kráľová, P Novák, M Novák - Nanobiotechnology in …, 2019 - Springer
Abstract “Neurodegenerative disease” is a term for a variety of disorders that primarily affect
neurons in the human brain and spinal cord. These diseases are presently incurable and …

Targeted drug delivery across the blood brain barrier in Alzheimer's disease

S Rocha - Current pharmaceutical design, 2013 - ingentaconnect.com
The discovery of drugs for Alzheimer's disease (AD) therapy that can also permeate the
blood brain barrier (BBB) is very difficult owing to its specificity and restrictive nature. The …

Development and optimization of hydroxyapatite-ofloxacin implants for possible bone delivery in osteomyelitis treatment

A Kumar Nayak, M Saquib Hasnain… - Current drug …, 2013 - ingentaconnect.com
The present study deals with preparation, optimization and in-vitro drug release study of
hydroxyapatite (HAp)-ofloxacin for bone-implantable delivery in osteomyelitis treatment. The …

Polymeric nanoparticles as oral delivery systems for encapsulation and release of polyphenolic compounds: Impact on quercetin antioxidant activity & bioaccessibility

H Pool, D Quintanar, JD Figueroa, JE H. Bechara… - Food Biophysics, 2012 - Springer
A delivery system containing polymeric (Eudragit) nanoparticles has been developed for
encapsulation and controlled release of bioactive flavonoids (quercetin). Nanoparticles were …

Taguchi design for optimization and development of antibacterial drug-loaded PLGA nanoparticles

H Chaudhary, V Kumar - International Journal of Biological …, 2014 - Elsevier
This research report was to develop Cefixime loaded polylactide-co-glycolide (PLGA)
nanoparticles using modified precipitation method. TEM analysis indicated formation of well …

Nanotherapeutics for Alzheimer's disease (AD): past, present and future

M Fazil, Shadab, S Baboota, JK Sahni… - Journal of drug …, 2012 - Taylor & Francis
Drug delivery to the brain still remains highly challenging for the treatment of Alzheimer's
disease (AD). The development of new practical treatment modalities for the treatment of AD …

Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems

S Gao, Y Xu, S Asghar, M Chen, L Zou… - Journal of Drug …, 2015 - Taylor & Francis
Among the materials for preparing the polymeric nanocarriers, poly (n-butylcyanoacrylate)(
PBCA), a polymer with medium length alkyl side chain, is of lower toxicity and proper …

Effect of physicochemical properties of biodegradable polymers on nano drug delivery

Sonam, H Chaudhary, V Arora, K Kholi… - Polymer Reviews, 2013 - Taylor & Francis
This review article is to explore the utilization of biodegradable polymers and their
associated physicochemical properties in nano drug delivery (NDD). The main hub of the …

Development and evaluation of metronidazole loaded microsponge based gel for superficial surgical wound infections

PM Kumar, A Ghosh - Journal of Drug Delivery Science and Technology, 2015 - Elsevier
The purpose of this study was to optimize, characterize and develop microsponge drug
delivery system for topical delivery. Antibacterial compound, metronidazole was selected as …

An alternative approach for improved entrapment efficiency of hydrophilic drug substance in PLGA nanoparticles by interfacial polymer deposition following solvent …

S Salatin, J Barar, M Barzegar-Jalali… - Jundishapur Journal of …, 2018 - brieflands.com
Background: Alzheimer's disease (AD) is an age-related and irreversible neurological
disorder. The low efficacy of current therapeutic strategies is related to both poor drug …