ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

Abstract Vitamin B12 (cobalamin, Cbl) is required as a cofactor by two human enzymes, 5‐
methyltetrahydrofolate‐homocysteine methyltransferase (MTR) and methylmalonyl‐CoA …

Human multidrug resistance protein 4 (hMRP4, also known as ABCC4), with a
representative topology of the MRP subfamily, translocates various substrates across the …

Abstract Acetyl-coenzyme A (Ac-CoA) is a core metabolite with essential roles throughout
cell physiology. These functions can be classified into energetics, biosynthesis, regulation …

ATP‐binding cassette (ABC) superfamily is one of the largest groups of primary active
transporters that could be found in all kingdoms of life from bacteria to humans. In humans …

Bilirubin is mainly generated from the breakdown of heme when red blood cells reach the
end of their lifespan. Accumulation of bilirubin in human body usually leads to various …

Human platelets contribute to hemostasis and thrombosis, the imbalance of which can
cause cardiovascular diseases. The activation and accumulation of platelets can be induced …

Adrenoleukodystrophy protein (ALDP) is responsible for the transport of very-longchain fatty
acids (VLCFAs) and corresponding CoA-esters across the peroxisomal membrane …

The ATP-binding cassette (ABC) transporters are one of the largest families of membrane-
bound proteins and exist in almost all living organisms from eubacteria to mammals. They …

Acyl-CoA binding domain containing 5 (ACBD5) is a critical player in handling very long
chain fatty acids (VLCFA) en route for peroxisomal β-oxidation. Mutations in ACBD5 lead to …