Cancer remains the second leading cause of mortality worldwide. In the course of this
multistage and multifactorial disease, a set of alterations takes place, with genetic and …

Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …

Butyrate, a metabolite of gut flora-mediated fermentation of dietary fibre, was analysed for
effects on expression of genes related to oxidative stress in primary human colon cells. An …

Simple Summary Non-steroidal anti-inflammatory drugs prevent the recurrence of
adenomatous polyps and colon cancer. At low doses, with presumed low gastrotoxicity …

Recent studies suggest that secreted phospholipases A 2 (sPLA 2 s) represent attractive
potential tumour biomarkers and therapeutic targets for various cancers. As a first step to …

Cyclooxygenases (COX-1 and COX-2) are key enzymes in several physiopathological
processes. Many adverse drugs reactions to NSAIDs are attributable to COX-inhibition. The …

The well-known anti-inflammatory and analgesic effects of the phytopharmacon willow bark
extract have been attributed to the content of salicin; however, pharmacological studies have …

Palbociclib is a specific CDK4/6 inhibitor that has been widely applied in multiple types of
tumors. Different from cytotoxic drugs, the anticancer mechanism of palbociclib mainly …

INTRODUCTION: Several conventional pharmaceuticals like non-steroidal anti-inflammatory
drugs (NSAIDS) or selective cyclooxygenase-2 (COX-2) inhibitors have been demonstrated …

Background Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are
not well known. Given the relevance of cytokines and other pro-inflammatory mediators in …