Modern-day environmental factors in the pathogenesis of osteoarthritis

F Berenbaum, IJ Wallace, DE Lieberman… - Nature Reviews …, 2018 - nature.com
The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this
Opinion article, we review the possibility that OA is an evolutionary mismatch disease, which …

[HTML][HTML] Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Z Liu, Y Zhuang, L Fang, C Yuan, X Wang, K Lin - Bioactive Materials, 2023 - Elsevier
Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain
and affects a patient's quality of life. However, currently, there is a lack of effective early …

Osteoarthritis and its management-Epidemiology, nutritional aspects and environmental factors

A Bortoluzzi, F Furini, CA Scirè - Autoimmunity reviews, 2018 - Elsevier
Osteoarthritis (OA) is the most prevalent chronic rheumatic diseases worldwide, with a
strong impact on individual and population health. OA is a clinically heterogeneous disease …

Metabolic syndrome-associated osteoarthritis

A Courties, J Sellam, F Berenbaum - Current opinion in …, 2017 - journals.lww.com
Metabolic syndrome-associated osteoarthritis : Current Opinion in Rheumatology Metabolic
syndrome-associated osteoarthritis : Current Opinion in Rheumatology Log in or Register …

Is osteoarthritis a metabolic disease?

J Sellam, F Berenbaum - Joint bone spine, 2013 - Elsevier
Obesity, together with aging and injury, is among the main risk factors for osteoarthritis.
Obesity-related osteoarthritis can affect not only the weight-bearing joints, but also the …

Hypertension meets osteoarthritis—revisiting the vascular aetiology hypothesis

K Ching, X Houard, F Berenbaum, C Wen - Nature Reviews …, 2021 - nature.com
Osteoarthritis (OA) is a whole-joint disease characterized by subchondral bone perfusion
abnormalities and neovascular invasion into the synovium and articular cartilage. In addition …

Osteoarthritis and type 2 diabetes mellitus: what are the links?

A Courties, J Sellam - Diabetes research and clinical practice, 2016 - Elsevier
Osteoarthritis (OA) is the most frequent joint disorder and one of the leading cause of
disability. During a long time, it was considered as the consequence of aging and …

Links between osteoarthritis and diabetes: implications for management from a physical activity perspective

SR Piva, AM Susko, SS Khoja… - Clinics in geriatric …, 2015 - geriatric.theclinics.com
Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) are 2 prevalent chronic diseases in
the United States. OA affects 14% of adults aged 25 years and older a Department of …

[HTML][HTML] The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms

KB King, AK Rosenthal - Osteoarthritis and cartilage, 2015 - Elsevier
Projected increases in the prevalence of both diabetes mellitus (DM) and osteoarthritis (OA)
ensure their common co-existence. In an era of increasing attention to personalized …

Systemic and local adipose tissue in knee osteoarthritis

E Belluzzi, H El Hadi, M Granzotto… - Journal of Cellular …, 2017 - Wiley Online Library
Osteoarthritis is a common chronic joint disorder affecting older people. The knee is the
major joint affected. The symptoms of osteoarthritis include limited range of motion, joint …