Mechanisms driving gender differences in asthma

H Fuseini, DC Newcomb - Current allergy and asthma reports, 2017 - Springer
Abstract Purpose of Review Many phenotypes of asthma exist, ranging from mild asthma
with onset during childhood to severe asthma with later onset, making asthma a broad …

Mechanisms and therapeutic strategies for non‐T2 asthma

E Sze, A Bhalla, P Nair - Allergy, 2020 - Wiley Online Library
Non‐T2 asthma is traditionally defined as asthma without features of T2 asthma. The
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

EFSA Panel on Food Contact Materials … - EFSA …, 2023 - Wiley Online Library
In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body
weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the …

Asthma and obesity: two diseases on the rise and bridged by inflammation

M Bantulà, J Roca-Ferrer, E Arismendi… - Journal of clinical …, 2021 - mdpi.com
Asthma and obesity are two epidemics affecting the developed world. The relationship
between obesity and both asthma and severe asthma appears to be weight-dependent …

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma

DF Choy, KM Hart, LA Borthwick, A Shikotra… - Science translational …, 2015 - science.org
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n= 51) …

Extracellular vesicles: novel communicators in lung diseases

A Mohan, S Agarwal, M Clauss, NS Britt… - Respiratory research, 2020 - Springer
The lung is the organ with the highest vascular density in the human body. It is therefore
perceivable that the endothelium of the lung contributes significantly to the circulation of …

Molecular targets for biological therapies of severe asthma

C Pelaia, C Crimi, A Vatrella, C Tinello… - Frontiers in …, 2020 - frontiersin.org
Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …

Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?

A Matucci, A Vultaggio, E Maggi, I Kasujee - Respiratory research, 2018 - Springer
Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in
pathophysiology and etiology. The heterogeneity of BA may be related to the inducing …

Sex and gender differences in lung disease

P Silveyra, N Fuentes, DE Rodriguez Bauza - Lung Inflammation in Health …, 2021 - Springer
Sex differences in the anatomy and physiology of the respiratory system have been widely
reported. These intrinsic sex differences have also been shown to modulate the …

[HTML][HTML] Just breathe: a review of sex and gender in chronic lung disease

R Somayaji, JD Chalmers - European Respiratory Review, 2022 - Eur Respiratory Soc
Chronic lung diseases are the third leading cause of death worldwide and are increasing in
prevalence over time. Although much of our traditional understanding of health and disease …