Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically
relevant tumor-targeting immune responses, which critically rely on the antigenicity of …

CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer.
During cancer progression, CTLs encounter dysfunction and exhaustion due to …

KRAS-LKB1 (KL) mutant lung cancers silence STING owing to intrinsic mitochondrial
dysfunction, resulting in T cell exclusion and resistance to programmed cell death (ligand) 1 …

Regulatory T cells (Tregs) represent a low number of T‐cell population under normal
conditions, and they play key roles for maintaining immune system in homeostasis. The …

The visceral adipose tissue (VAT) of lean mice hosts a unique population of regulatory T
cells (Tregs) that have a distinct transcriptome and T cell receptor (TCR) repertoire and …

Tumor microenvironment (TME) is a host for a complex network of heterogeneous stromal
cells with overlapping or opposing functions depending on the dominant signals within this …

A pan-sarbecovirus or pan-betacoronavirus vaccine that can prevent current and potential
future beta-coronavirus infections is important for fighting possible future pandemics. Here …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is characterized by diverse immune regulatory systems involving cell proliferation …

Simple Summary Interferons are cytokines that play key roles in the activation of cellular
components of the immune response, such as dendritic cells, macrophages and T cells …

Immunogenic cell death (ICD) is a regulated cell death (RCD) pathway. In response to
physical and chemical signals, tumor cells activate specific signaling pathways that stimulate …