IGF-I receptor (IGF-IR) signaling and functions are mediated through the activities of a
complex molecular network of positive (eg., type I IGF) and negative (eg., the type II IGF …

Bcl-2-associated athanogene (BAG)-family proteins are BAG domain-containing proteins
that interact with the heat shock proteins 70, both constitutive Hsc70 and inducible Hsp70 …

Protein kinase Cδ (PKCδ) mediates apoptosis downstream of many apoptotic stimuli.
Because of its ubiquitous expression, tight regulation of the proapoptotic function of PKCδ is …

Purpose: Dysregulation of the insulin-like growth factor-I receptor (IGF-IR) signaling pathway
has been implicated in the development of many types of tumors, including prostate, colon …

IGF-I action is essential for the regulation of tissue formation and remodeling, bone growth,
prenatal growth, brain development, and muscle metabolism. Cellular effects of IGF-I are …

Insulin-like growth factor I (IGF-I) has been previously shown to promote survival of
oligodendrocyte progenitors; however, the underlying mechanisms are not fully understood …

Growth factors play important roles in synapse formation. Mouse models of neuropsychiatric
diseases suggest that defects in synaptogenic growth factors, their receptors, and signaling …

Peptide growth factors contribute to the pathogenesis of cardiovascular diseases by
inducing a variety of cellular responses including anti-apoptotic effects. Several of the …

Transitional cell carcinoma of the urinary bladder is the second most common genitourinary
malignancy in people in the United States. Cyclooxygenase-2 (COX-2) is overexpressed in …

ARK5 is a tumor progression-associated factor that is directly phosphorylated by AKT at
serine 600 in the regulatory domain, but phosphorylation at the conserved threonine residue …