Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus
SA Chalmers, J Wen, J Doerner, A Stock… - Arthritis Research & …, 2018 - Springer
Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that
affects different end organs, including skin and brain. We and others have previously shown …
affects different end organs, including skin and brain. We and others have previously shown …
Centrally acting angiotensin-converting enzyme inhibitor suppresses type I interferon responses and decreases inflammation in the periphery and the CNS in lupus …
C Nocito, C Lubinsky, M Hand, S Khan, T Patel… - Frontiers in …, 2020 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-
organ damage. Neuropsychiatric lupus (NPSLE) is one of the most common manifestations …
organ damage. Neuropsychiatric lupus (NPSLE) is one of the most common manifestations …
Treatment with the CSF1R antagonist GW2580, sensitizes microglia to reactive oxygen species
K Soto-Diaz, M Vailati-Riboni, AY Louie… - Frontiers in …, 2021 - frontiersin.org
Microglia activation and proliferation are hallmarks of many neurodegenerative disorders
and may contribute to disease pathogenesis. Neurons actively regulate microglia survival …
and may contribute to disease pathogenesis. Neurons actively regulate microglia survival …
[HTML][HTML] CXCL13 neutralization attenuates neuropsychiatric manifestations in lupus-prone mice
MW Huang, AD Stock, C Putterman - Frontiers in Immunology, 2021 - frontiersin.org
Neuropsychiatric lupus (NPSLE), the nervous system presentation of systemic lupus
erythematosus (SLE), remains challenging to treat due to its unclear pathogenesis and lack …
erythematosus (SLE), remains challenging to treat due to its unclear pathogenesis and lack …
The role of microglial depletion approaches in pathological condition of CNS
F Tahmasebi, S Barati - Cellular and Molecular Neurobiology, 2023 - Springer
Microglia are the primary immune cells of the central nervous system (CNS) that comprise
about 5–12% of all cells in the brain. These cells are the first line of defense that protects the …
about 5–12% of all cells in the brain. These cells are the first line of defense that protects the …
CSF-1R inhibition attenuates ischemia-induced renal injury and fibrosis by reducing Ly6C+ M2-like macrophage infiltration
X Deng, Q Yang, Y Wang, C Zhou, Y Guo, Z Hu… - International …, 2020 - Elsevier
Acute kidney injury (AKI) to chronic kidney disease (CKD) progression has become a life-
threatening disease. However, an effective therapeutic strategy is still needed. The …
threatening disease. However, an effective therapeutic strategy is still needed. The …
PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus
Abstract Systematic Lupus Erythematosus (SLE) is an autoimmune syndrome of unclear
etiology. While T and B cell abnormalities contribute to disease pathogenesis, recent work …
etiology. While T and B cell abnormalities contribute to disease pathogenesis, recent work …
NF-kB signaling in myeloid cells mediates the pathogenesis of immune-mediated nephritis
SA Chalmers, SJ Garcia, JA Reynolds, L Herlitz… - Journal of …, 2019 - Elsevier
Immune-mediated glomerulonephritis is a serious end organ pathology that commonly
affects patients with systemic lupus erythematosus (SLE). A classic murine model used to …
affects patients with systemic lupus erythematosus (SLE). A classic murine model used to …
Neuropsychiatric lupus erythematosus: Focusing on autoantibodies
J Wang, J Xu, P Yang - Journal of Autoimmunity, 2022 - Elsevier
Patients with systemic lupus erythematosus (SLE) frequently suffer from nervous system
complications, termed neuropsychiatric lupus erythematosus (NPLE). NPLE accounts for the …
complications, termed neuropsychiatric lupus erythematosus (NPLE). NPLE accounts for the …
Urine macrophages reflect kidney macrophage content during acute tubular interstitial and glomerular injury
P Sun, X Zhou, J Su, C Wang, X Yu, T Su, G Liu… - Clinical …, 2019 - Elsevier
Macrophage polarization is a major contributing factor in acute kidney injury (AKI). We aim to
determine its biomarker value in differentiating etiologic causes of various intrinsic renal AKI …
determine its biomarker value in differentiating etiologic causes of various intrinsic renal AKI …