Prader–Willi syndrome (PWS) is a neurodevelopmental disorder that arises from lack of
expression of paternally inherited genes known to be imprinted and located in the …

Growth hormone (GH) is synthesised and secreted by the somatotroph cells of the anterior
lobe of the pituitary gland. Its actions involve multiple organs and systems, affecting …

The growth hormone receptor has been an archetype for ligand-induced receptor
dimerisation in cytokine receptor signalling. However, we now know that it exists as a …

Growth hormone (GH) regulates insulin-like growth factor (IGF)-I production primarily
through activation of the GH receptor (GHR)-signal transducer and activator of transcription …

GH insensitivity (GHI) presents in childhood with growth failure and in its severe form is
associated with extreme short stature and dysmorphic and metabolic abnormalities. In …

The Sackler Institute for Nutrition Science and the World Health Organization (WHO) have
worked together to formulate a research agenda for nutrition science. Undernutrition of …

Objectives Mutations in the genes encoding the transcription factors PROP1 and POUF‐1
(Pit‐1) have been reported as common causes of combined pituitary hormone deficiency …

After a proper medical history, growth analysis and physical examination of a short child,
followed by radiological and laboratory screening, the clinician may decide to perform …

Growth hormone (GH) is a polypeptide hormone, secreted by somatotropic cells of the
anterior part of the hypophysis. Its application in therapy, first limited to GH deficient children …

Context: Hesx1 is one of the earliest homeodomain transcription factors expressed during
pituitary development. Very few HESX1 mutations have been identified in humans; although …