Abstract Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of
ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD (P) H axis and …

Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …

Background Sudden sensorineural hearing loss (SSNHL) is an abrupt loss of hearing, still
idiopathic in most of cases. Several mechanisms have been proposed including genetic and …

Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron
dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have …

The nucleus pulposus is in a hypoxic environment in the human body, and when
intervertebral disc degeneration (IVDD) occurs, the hypoxic environment is disrupted …

Hearing loss is one of the most difficult sensory disorders to treat because of complicated
anatomical and physiological barriers, which result in systemic administration, making it …

If the term “genetics” is a relatively recent proposition, introduced in 1905 by English
biologist William Bateson, who rediscovered and spread in the scientific community …

Oxidative stress is the common mechanism of sensorineural hearing loss (SNHL) caused by
many factors, such as noise, drugs and ageing. Here, we used tert-butyl hydroperoxide (t …

Early detection of noise-induced hearing loss (NIHL) in patients with long-term noise
exposure is vital for improving public health and reducing social burden. However, at …