We sequenced more than 52,500 single cells from embryonic day 11.5 (E11. 5)
postembryonic day 5 (P5) gonads and performed lineage tracing to analyze primordial …

In female mammals, meiotic prophase one begins during fetal development. Oocytes
transition through the prophase one substages consisting of leptotene, zygotene, and …

In fetal females, oogonia proliferate immediately after sex determination. The progress of
mitosis in oogonia proceeds so rapidly that the incompletely divided cytoplasm of the sister …

Germ-cell transcription factors control gene networks that regulate oocyte differentiation and
primordial follicle formation during early, postnatal mouse oogenesis. Taking advantage of …

In mammals, oocytes are arrested at the diplotene stage of meiosis I until the pre-ovulatory
luteinizing hormone (LH) surge triggers meiotic resumption through the signals in follicular …

Background Ovarian folliculogenesis is a tightly regulated process leading to the formation
of functional oocytes and involving successive quality control mechanisms that monitor …

Pumilio/FBF (PUF) proteins are a highly conserved family of translational regulators. The
Drosophila PUF protein, Pumilio, is crucial for germline establishment and fertility. In …

Gonadal sex in most mammals is determined based on sex differentiation of the supporting
cell lineages. In mouse XY gonads, SRY induces SOX9 upregulation and subsequent FGF9 …

Zinc oxide nanoparticles (nZnO) have been shown to have higher toxic effects likely due to
their ion-shedding ability and low solubility under neutral conditions. In order to investigate …

Background Ovarian follicles, which are the basic units of female reproduction, are
composed of oocytes and surrounding somatic (pre) granulosa cells (GCs). A recent study …