Cannabidiol: pharmacology and therapeutic targets

SC Britch, S Babalonis, SL Walsh - Psychopharmacology, 2021 - Springer
Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis

G Hindley, K Beck, F Borgan, CE Ginestet… - The Lancet …, 2020 - thelancet.com
Background Approximately 188 million people use cannabis yearly worldwide, and it has
recently been legalised in 11 US states, Canada, and Uruguay for recreational use. The …

[HTML][HTML] Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD: THC ratios

A Englund, D Oliver, E Chesney, L Chester… - …, 2023 - nature.com
As countries adopt more permissive cannabis policies, it is increasingly important to identify
strategies that can reduce the harmful effects of cannabis use. This study aimed to determine …

Assessment of orally administered Δ9-tetrahydrocannabinol when coadministered with cannabidiol on Δ9-tetrahydrocannabinol pharmacokinetics and …

CA Zamarripa, TR Spindle, R Surujunarain… - JAMA Network …, 2023 - jamanetwork.com
Importance Controlled clinical laboratory studies have shown that cannabidiol (CBD) can
sometimes attenuate or exacerbate the effects ofΔ9-tetrahydrocannabinol (Δ9-THC). No …

How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review

AM Freeman, K Petrilli, R Lees, C Hindocha… - Neuroscience & …, 2019 - Elsevier
The recent liberalisation of cannabis regulation has increased public and scientific debate
about its potential benefits and risks. A key focus has been the extent to which cannabidiol …

[HTML][HTML] Substance-induced psychoses: an updated literature review

A Fiorentini, F Cantù, C Crisanti, G Cereda… - Frontiers in …, 2021 - frontiersin.org
Background: On the current psychopharmacological panorama, the variety of substances
able to provoke an episode of acute psychosis is rapidly increasing. Such psychotic …

'Standard THC units': a proposal to standardize dose across all cannabis products and methods of administration

TP Freeman, V Lorenzetti - Addiction, 2020 - Wiley Online Library
Abstract Background and Aims Cannabis products are becoming increasingly diverse, and
vary considerably in concentrations of∆ 9‐tetrahydrocannabinol (THC) and cannabidiol …

Association of ketamine with psychiatric symptoms and implications for its therapeutic use and for understanding schizophrenia: a systematic review and meta …

K Beck, G Hindley, F Borgan, C Ginestet… - JAMA network …, 2020 - jamanetwork.com
Importance Ketamine hydrochloride is increasingly used to treat depression and other
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …

A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute …

N Solowij, S Broyd, L Greenwood, H van Hell… - European archives of …, 2019 - Springer
Access to cannabis and cannabinoid products is increasing worldwide for recreational and
medicinal use. Two primary compounds within cannabis plant matter, Δ 9 …

[HTML][HTML] Cannabis, the Endocannabinoid System and Immunity—the Journey from the Bedside to the Bench and Back

O Almogi-Hazan, R Or - International journal of molecular sciences, 2020 - mdpi.com
The Cannabis plant contains numerous components, including cannabinoids and other
active molecules. The phyto-cannabinoid activity is mediated by the endocannabinoid …