The epigenome is a key determinant of transcriptional output. Perturbations within the
epigenome are thought to be a key feature of many, perhaps all cancers, and it is now clear …

Congenital heart disease (CHD) affects nearly 1% of the population. It is a complex disease,
which may be caused by multiple genetic and environmental factors. Studies in human …

Abstract NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain
(NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar …

Constitutive NF-κB activation by proinflammatory cytokines plays a major role in cancer
progression. However, the underlying mechanism is still unclear. We report here that histone …

Trimethylation of Lys36 in histone H3 (H3K36me3) coordinates events associated with the
elongation phase of transcription and is also emerging as an important epigenetic regulator …

Abstract 53BP1 and other DNA damage response (DDR) proteins form foci at double-strand
breaks (DSBs) which promote their repair by nonhomologous end joining (NHEJ). Focal …

Genetic modification is critically enabling for studies addressing specification and
maintenance of cell fate; however, methods for engineering modifications are inefficient. We …

The Sotos syndrome gene product, NSD1, is a SET domain histone methyltransferase that
primarily dimethylates nucleosomal histone H3 lysine 36 (H3K36). To date, the intrinsic …

Methylation of histone H3K36 in higher eukaryotes is mediated by multiple
methyltransferases. Set2-related H3K36 methyltransferases are targeted to genes by …

Murine embryonic stem (ES) cells are defined by continuous self-renewal and pluripotency.
A diverse repertoire of protein isoforms arising from alternative splicing is expressed in ES …