Nociplastic pain is the semantic term suggested by the international community of pain
researchers to describe a third category of pain that is mechanistically distinct from …

In agreement with the International Association for the Study of Pain, chronic pain is an
unpleasant sensory and emotional experience associated with actual or potential tissue …

Background It is nearly impossible to overestimate the burden of chronic pain, which is
associated with enormous personal and socioeconomic costs. Chronic pain is the leading …

Opioids are widely prescribed for pain management, and it is estimated that 40% of adults in
the United States use prescription opioids every year. Opioid misuse leads to high mortality …

The US is grappling with an opioid epidemic, with millions of adults on long-term opioid
therapy (LTOT). Although patients often report pain relief and improved daily function with …

Background Hitherto only studies with selected populations have found an increased all-
cause mortality of some selected opioids compared to selected non-opioids for chronic non …

Background Opioid use for chronic non‐cancer pain (CNCP) is under debate. In the
absence of pan‐European guidance on this issue, a position paper was commissioned by …

Chronic pain is one of the most common reasons adults seek medical care and is often
managed with opioid analgesics; however, opioids may cause respiratory depression by …

Background Chronic musculoskeletal pain and insomnia frequently co-occur and are known
independent risk factors for anxiety and depression. However, the interplay between these …

Chronic low back pain (LBP) shares a bidirectional relationship with sleep disturbance.
Analgesics are often used for chronic LBP management however, the effects on sleep have …