As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …

Pyroptosis is a kind of programmed cell death closely related to inflammation. The pathways
that mediate pyroptosis can be divided into the Caspase-1-dependent canonical pathway …

Simple Summary Statins are crucial for managing lipid disorders by inhibiting HMG-CoA
reductase, reducing cholesterol levels, and lowering cardiovascular disease risk. Beyond …

Statins is widely used in clinical practice as lipid-lowering drugs and has been proven to be
effective in the treatment of cardiovascular, endocrine, metabolic syndrome and other …

Cardiovascular disease (CVD) is the main cause of death worldwide. Atherosclerosis is the
underlying pathological basis of CVD. Mitochondrial homeostasis is maintained through the …

Methods Appropriate inflammatory responses and the induction of pyroptosis enhance the
clearance of pathogens and increase innate immunity. Results However, excessive …

Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is
characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss …

Cardiomyocyte death is one of the major mechanisms contributing to the development of
myocardial infarction (MI) and myocardial ischemia/reperfusion (MI/R) injury. Due to the …

Cardiovascular disease (CVD) is one of the most important diseases endangering human
life. The pathogenesis of CVDs is complex. Pyroptosis, which differs from traditional …