Recombinant protein vaccines, a proven approach against coronavirus pandemics
With the COVID-19 pandemic now ongoing for close to a year, people all over the world are
still waiting for a vaccine to become available. The initial focus of accelerated global …
still waiting for a vaccine to become available. The initial focus of accelerated global …
Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing
R O'Flaherty, A Bergin, E Flampouri, LM Mota… - Biotechnology …, 2020 - Elsevier
The manufacturing of recombinant protein is traditionally undertaken in mammalian cell
culture. Today, speed, cost and safety are the primary considerations for process …
culture. Today, speed, cost and safety are the primary considerations for process …
Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives
J Dumont, D Euwart, B Mei, S Estes… - Critical reviews in …, 2016 - Taylor & Francis
Biotherapeutic proteins represent a mainstay of treatment for a multitude of conditions, for
example, autoimmune disorders, hematologic disorders, hormonal dysregulation, cancers …
example, autoimmune disorders, hematologic disorders, hormonal dysregulation, cancers …
[HTML][HTML] Therapeutic glycoprotein production in mammalian cells
ME Lalonde, Y Durocher - Journal of biotechnology, 2017 - Elsevier
Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …
production towards mammalian cell expression systems. The presence of glycosylation …
[HTML][HTML] Site-specific N-glycosylation characterization of recombinant SARS-CoV-2 spike proteins
The glycoprotein spike (S) on the surface of severe acute respiratory syndrome coronavirus
(SARS-CoV-2) is a determinant for viral invasion and host immune response. Herein, we …
(SARS-CoV-2) is a determinant for viral invasion and host immune response. Herein, we …
[HTML][HTML] What does plant-based vaccine technology offer to the fight against COVID-19?
S Rosales-Mendoza, VA Márquez-Escobar… - Vaccines, 2020 - mdpi.com
The emergence of new pathogenic viral strains is a constant threat to global health, with the
new coronavirus strain COVID-19 as the latest example. COVID-19, caused by the SARS …
new coronavirus strain COVID-19 as the latest example. COVID-19, caused by the SARS …
Structural basis for the docking of mTORC1 on the lysosomal surface
The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth
in response to nutrients and growth factors. Nutrients promote its translocation to the …
in response to nutrients and growth factors. Nutrients promote its translocation to the …
Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation
D Ghaderi, M Zhang, N Hurtado-Ziola… - Biotechnology and …, 2012 - Taylor & Francis
One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic
glycoproteins. Today, these molecules play a major role in the treatment of various diseases …
glycoproteins. Today, these molecules play a major role in the treatment of various diseases …
[图书][B] Gene cloning and DNA analysis: an introduction
TA Brown - 2020 - books.google.com
Known worldwide as the standard introductory text to this important and exciting area of
study, Gene Cloning and DNA Analysis: An Introduction, 8th Edition preserves the tradition …
study, Gene Cloning and DNA Analysis: An Introduction, 8th Edition preserves the tradition …
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus
J Stevens, O Blixt, TM Tumpey, JK Taubenberger… - science, 2006 - science.org
The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic
Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs …
Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs …