[HTML][HTML] Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum
Y Baradaran-Heravi, C Van Broeckhoven… - Neurobiology of …, 2020 - Elsevier
Stress granules (SGs) are dynamic membraneless compartments composed out of RNA-
binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to …
binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to …
RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
SM García-Mauriño, F Rivero-Rodríguez… - Frontiers in molecular …, 2017 - frontiersin.org
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs)
that determine mRNA fate, thereby influencing multiple cellular functions across biological …
that determine mRNA fate, thereby influencing multiple cellular functions across biological …
Improving Martini 3 for disordered and multidomain proteins
Coarse-grained molecular dynamics simulations are a useful tool to determine
conformational ensembles of proteins. Here, we show that the coarse-grained force field …
conformational ensembles of proteins. Here, we show that the coarse-grained force field …
Post-translational control of RNA-binding proteins and disease-related dysregulation
A Velázquez-Cruz, B Baños-Jaime… - Frontiers in molecular …, 2021 - frontiersin.org
Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …
Linking hnRNP function to ALS and FTD pathology
Following years of rapid progress identifying the genetic underpinnings of amyotrophic
lateral sclerosis (ALS) and related diseases such as frontotemporal dementia (FTD) …
lateral sclerosis (ALS) and related diseases such as frontotemporal dementia (FTD) …
The TIA1 RNA-binding protein family regulates EIF2AK2-mediated stress response and cell cycle progression
TIA1 and TIAL1 encode a family of U-rich element mRNA-binding proteins ubiquitously
expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins …
expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins …
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
M Pabis, GM Popowicz, R Stehle… - Nucleic acids …, 2019 - academic.oup.com
HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …
Applications of isothermal titration calorimetry–the research and technical developments from 2011 to 2015
RJ Falconer - Journal of Molecular Recognition, 2016 - Wiley Online Library
Isothermal titration calorimetry is a widely used biophysical technique for studying the
formation or dissociation of molecular complexes. Over the last 5 years, much work has …
formation or dissociation of molecular complexes. Over the last 5 years, much work has …
Unraveling the pathways to neuronal homeostasis and disease: mechanistic insights into the role of RNA-binding proteins and associated factors
The timing, dosage and location of gene expression are fundamental determinants of brain
architectural complexity. In neurons, this is, primarily, achieved by specific sets of trans …
architectural complexity. In neurons, this is, primarily, achieved by specific sets of trans …
CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
U1 snRNP plays a critical role in 5ʹ-splice site recognition and is a frequent target of
alternative splicing factors. These factors transiently associate with human U1 snRNP and …
alternative splicing factors. These factors transiently associate with human U1 snRNP and …