Paracetamol–An old drug with new mechanisms of action
GW Przybyła, KA Szychowski… - Clinical and Experimental …, 2021 - Wiley Online Library
Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …
the world. Despite its popularity and use for many years, the safety of its application and its …
Molecular sensors of blood flow in endothelial cells
Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …
[HTML][HTML] Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes
The joints of mammals are lined with cartilage, comprised of individual chondrocytes
embedded in a specialized extracellular matrix. Chondrocytes experience a complex …
embedded in a specialized extracellular matrix. Chondrocytes experience a complex …
Mechanosensitive TRPV4 is required for crystal-induced inflammation
Crystal structures activate innate immune cells, especially macrophages and initiate
inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 …
inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 …
Modulation of the TRPV4 ion channel as a therapeutic target for disease
Abstract Transient Receptor Potential Vanilloid 4 (TRPV4) is a broadly expressed,
polymodally gated ion channel that plays an important role in many physiological and …
polymodally gated ion channel that plays an important role in many physiological and …
[HTML][HTML] The TRPV4 agonist GSK1016790A regulates the membrane expression of TRPV4 channels
S Baratchi, P Keov, WG Darby, A Lai… - Frontiers in …, 2019 - frontiersin.org
TRPV4 is a non-selective cation channel that tunes the function of different tissues including
the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective …
the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective …
[HTML][HTML] Role of TRPM7 in cancer: potential as molecular biomarker and therapeutic target
NS Yee - Pharmaceuticals, 2017 - mdpi.com
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed ion channel with intrinsic kinase activity. Molecular and electrophysiological …
expressed ion channel with intrinsic kinase activity. Molecular and electrophysiological …
Investigational drugs in early phase clinical trials targeting thermotransient receptor potential (thermoTRP) channels
A Fernández-Carvajal, R González-Muñiz… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Thermo transient receptor potential (thermoTRP) channels are some of the most
intensely pursued therapeutic targets of the past decade. They are considered promising …
intensely pursued therapeutic targets of the past decade. They are considered promising …
TRPV4 antagonists: A patent review (2015–2020)
BG Lawhorn, EJ Brnardic, DJ Behm - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Transient receptor potential vanilloid 4 (TRPV4) is an ion channel that is widely
expressed and is activated by numerous chemical, osmotic and mechanical stimuli. By …
expressed and is activated by numerous chemical, osmotic and mechanical stimuli. By …
Recent advances in TRPV4 agonists and antagonists
BG Lawhorn, EJ Brnardic, DJ Behm - Bioorganic & Medicinal Chemistry …, 2020 - Elsevier
TRPV4 is a ubiquitously expressed, non-selective cation channel activated by a range of
stimuli including hypotonicity, temperature, pH, stretch and endogenous ligands. Agents that …
stimuli including hypotonicity, temperature, pH, stretch and endogenous ligands. Agents that …