Computer analysis of computed tomography scans of the lung: a survey

I Sluimer, A Schilham, M Prokop… - IEEE transactions on …, 2006 - ieeexplore.ieee.org
Current computed tomography (CT) technology allows for near isotropic, submillimeter
resolution acquisition of the complete chest in a single breath hold. These thin-slice chest …

State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease

EA Hoffman, BA Simon, G McLennan - Proceedings of the American …, 2006 - atsjournals.org
With advances in multidetector-row computed tomography (MDCT), it is now possible to
image the lung in 10 s or less and accurately extract the lungs, lobes, and airway tree to the …

Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways

CL Lin, MH Tawhai, G McLennan… - Respiratory physiology & …, 2007 - Elsevier
A computational fluid dynamics technique is applied to understand the relative importance of
the upper and intra-thoracic airways and their role in determining central airflow patterns …

A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis

A Busacker, JD Newell Jr, T Keefe, EA Hoffman… - Chest, 2009 - Elsevier
Background Patients with severe asthma have increased physiologically measured air
trapping; however, a study using CT measures of air trapping has not been performed. This …

Regional deposition of particles in an image-based airway model: large-eddy simulation and left-right lung ventilation asymmetry

AR Lambert, PT O'shaughnessy… - Aerosol Science and …, 2011 - Taylor & Francis
Regional deposition and ventilation of particles by generation, lobe and lung during steady
inhalation in a computed tomography (CT) based human airway model are investigated …

Blood flow redistribution and ventilation-perfusion mismatch during embolic pulmonary arterial occlusion

KS Burrowes, AR Clark, MH Tawhai - Pulmonary circulation, 2011 - journals.sagepub.com
Acute pulmonary embolism causes redistribution of blood in the lung, which impairs
ventilation/perfusion matching and gas exchange and can elevate pulmonary arterial …

On intra-and intersubject variabilities of airflow in the human lungs

J Choi, MH Tawhai, EA Hoffman, CL Lin - Physics of Fluids, 2009 - pubs.aip.org
The effects of intra-and intersubject variabilities in airway geometry on airflow in the human
lungs are investigated by large eddy simulation. The airway models of two human subjects …

Pulmonary CT and MRI phenotypes that help explain chronic pulmonary obstruction disease pathophysiology and outcomes

EA Hoffman, DA Lynch, RG Barr… - Journal of Magnetic …, 2016 - Wiley Online Library
Pulmonary x‐ray computed tomographic (CT) and magnetic resonance imaging (MRI)
research and development has been motivated, in part, by the quest to subphenotype …

Functional imaging: CT and MRI

EJR van Beek, EA Hoffman - Clinics in chest medicine, 2008 - Elsevier
Numerous imaging techniques permit evaluation of regional pulmonary function. Contrast-
enhanced CT methods now allow assessment of vasculature and lung perfusion …

Towards a virtual lung: multi-scale, multi-physics modelling of the pulmonary system

KS Burrowes, AJ Swan… - … Transactions of the …, 2008 - royalsocietypublishing.org
The essential function of the lung, gas exchange, is dependent on adequate matching of
ventilation and perfusion, where air and blood are delivered through complex branching …