The promise and potential of brain organoids

L Smirnova, T Hartung - Advanced Healthcare Materials, 2024 - Wiley Online Library
Brain organoids are 3D in vitro culture systems derived from human pluripotent stem cells
that self‐organize to model features of the (developing) human brain. This review examines …

[图书][B] Handbook on the Toxicology of Metals: Volume II: Specific Metals

GF Nordberg, M Costa - 2021 - books.google.com
Handbook on the Toxicology of Metals, Volume II: Specific Metals, Fifth Edition provides
complete coverage of 38 individual metals and their compounds. This volume is the second …

Human embryos, induced pluripotent stem cells, and organoids: models to assess the effects of environmental plastic pollution

D Miloradovic, D Pavlovic, MG Jankovic… - Frontiers in Cell and …, 2021 - frontiersin.org
For a long time, animal models were used to mimic human biology and diseases. However,
animal models are not an ideal solution due to numerous interspecies differences between …

Internalization and toxicity of polystyrene nanoplastics on inmortalized human neural stem cells

MC González-Caballero, M de Alba González… - Chemosphere, 2024 - Elsevier
Global plastic production has increased exponentially in recent decades, and a significant
part of it persists in the environment, where it degrades into microplastics and nanoplastics …

[HTML][HTML] Developmental neurotoxicity induced by glutaraldehyde in neuron/astrocyte co-cultured cells and zebrafish

HN Oh, D Yoo, S Park, S Lee, WK Kim - Ecotoxicology and Environmental …, 2022 - Elsevier
The genotoxicity, development toxicity, carcinogenicity, and acute or chronic toxic effects of
glutaraldehyde (GA), particularly during occupational exposure through its use as a fixative …

Roadbumps at the Crossroads of Integrating Behavioral and In Vitro Approaches for Neurotoxicity Assessment

GJ Harry, S Mcbride, SK Witchey… - Frontiers in …, 2022 - frontiersin.org
With the appreciation that behavior represents the integration and complexity of the nervous
system, neurobehavioral phenotyping and assessment has seen a renaissance over the last …

Zebrafish and nematodes as whole organism models to measure developmental neurotoxicity

S Hughes, EVS Hessel - Critical Reviews in Toxicology, 2024 - Taylor & Francis
Despite the growing epidemiological evidence of an association between toxin exposure
and developmental neurotoxicity (DNT), systematic testing of DNT is not mandatory in …

Human neural stem cells in developmental neurotoxicology: Current scenario and future prospects

A Rosca, R Coronel, V López-Alonso, I Liste… - Advances in …, 2023 - Elsevier
It is widely known that any alteration in basic neurodevelopmental processes and exposure
to environmental chemicals early in life, contributes to widespread subclinical …

Neuron Characterization in Complex Cultures Using a Combined YOLO and U-Net Segmentation Approach

P Puerta, B Öztürk, SB Khojasteh, VM González… - … Conference on Soft …, 2023 - Springer
This work presents a novel approach for the automated characterization of neurons in
primary culture from phase-contrast images. Direct characterization of neurons from these …

Check for updates Neuron Characterization in Complex Cultures Using a Combined YOLO and U-Net Segmentation Approach

P Puerta¹, B Öztürk¹, SB Khojasteh¹… - … Conference on Soft …, 2023 - books.google.com
This work presents a novel approach for the automated characterization of neurons in
primary culture from phase-contrast images. Direct characterization of neurons from these …