Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant
biological roles and are implicated in many diseases, such as cancer and inflammation …

Adagen, an enzyme replacement treatment for adenosine deaminase deficiency, was the
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …

In this study, we designed and fabricated a novel amphiphilic biodegradable triblock N-(2-
hydroxypropyl methyl) acrylamide (HPMA) copolymer-gadolinium-paclitaxel-Cyanine5. 5 …

In the past several decades, nanosized drug delivery systems with various targeting
functions and controlled drug release capabilities inside targeted tissues or cells have been …

Herein, new biodegradable star polymer–doxorubicin conjugates designed for passive
tumor targeting were investigated, and their synthesis, physico-chemical characterization …

Stable gadolinium chelates are widely used as the contrast agents (CAs) for magnetic
resonance imaging (MRI). Conjugation of the chelates onto macromolecular carriers forms …

Although folate exhibits many advantages over other targeting ligands, it has one major
defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2 …

We designed and synthesized a new delivery system for the anticancer drug doxorubicin
based on a biocompatible hydrophilic poly (2-ethyl-2-oxazoline)(PEtOx) carrier with linear …

Animal models, particularly rodents, are major translational models for evaluating novel
anticancer therapeutics. In this review, different types of nanostructure‐based …

Nanomedicine systems aim to improve the biodistribution and the target site accumulation of
systemically applied (chemo-) therapeutics. By increasing drug localization at the …