Biological rationale for the design of polymeric anti-cancer nanomedicines
Understanding the biological features of cancer is the basis for designing efficient anti-
cancer nanomedicines. On one hand, important therapeutic targets for anti-cancer …
cancer nanomedicines. On one hand, important therapeutic targets for anti-cancer …
Anti-CD20 multivalent HPMA copolymer-Fab′ conjugates for the direct induction of apoptosis
A hybrid biomimetic system comprising high-molecular-weight, linear copolymer of N-(2-
hydroxypropyl) methacrylamide (HPMA) grafted with multiple Fab′ fragments of anti-CD20 …
hydroxypropyl) methacrylamide (HPMA) grafted with multiple Fab′ fragments of anti-CD20 …
HPMA-based polymeric conjugates in anticancer therapeutics
Highlights•HPMA (N-2-hydroxypropylmethacrylamide) is an emerging polymeric alternative
for drug delivery applications.•HPMA can be potentially conjugated to develop copolymers …
for drug delivery applications.•HPMA can be potentially conjugated to develop copolymers …
N-(2-hydroxypropyl) methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging
Tumor-targeted photodynamic therapy (PDT) using polymeric photosensitizers is a
promising therapeutic strategy for cancer treatment. In this study, we synthesized a pHPMA …
promising therapeutic strategy for cancer treatment. In this study, we synthesized a pHPMA …
SET-LRP of N-(2-hydroxypropyl) methacrylamide in H 2 O
NH Nguyen, C Rodriguez-Emmenegger, E Brynda… - Polymer …, 2013 - pubs.rsc.org
SET-LRP of N-(2-hydroxypropyl)methacrylamide in H 2 O - Polymer Chemistry (RSC
Publishing) DOI:10.1039/C3PY00220A Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/C3PY00220A Royal Society of Chemistry View PDF VersionPrevious …
Hybrid polymeric hydrogels via peptide nucleic acid (PNA)/DNA complexation
This work presents a new concept in hybrid hydrogel design. Synthetic water-soluble N-(2-
hydroxypropyl) methacrylamide (HPMA) polymers grafted with multiple peptide nucleic acids …
hydroxypropyl) methacrylamide (HPMA) polymers grafted with multiple peptide nucleic acids …
[HTML][HTML] A two-step pretargeted nanotherapy for CD20 crosslinking may achieve superior anti-lymphoma efficacy to rituximab
The use of rituximab, an anti-CD20 mAb, in combination with chemotherapy is the current
standard for the treatment of B-cell lymphomas. However, because of a significant number of …
standard for the treatment of B-cell lymphomas. However, because of a significant number of …
Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry
M Talelli, K Morita, CJF Rijcken, RWM Aben… - Bioconjugate …, 2011 - ACS Publications
Doxorubicin is an anthracycline anticancer agent that is commonly used in the treatment of a
variety of cancers, but its application is associated with severe side effects. Biodegradable …
variety of cancers, but its application is associated with severe side effects. Biodegradable …
Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system
We report a rigorous investigation into the detailed structure of nanoparticles already shown
to be successful drug delivery nanocarriers. The basic structure of the drug conjugates …
to be successful drug delivery nanocarriers. The basic structure of the drug conjugates …
Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights
C Rodriguez‐Emmenegger… - Macromolecular …, 2011 - Wiley Online Library
Among the class of zwitterionic polymers poly (carboxybetaine) s (poly (CB) s) are unique,
emerging as the only ultra‐low fouling materials known allowing the preparation of …
emerging as the only ultra‐low fouling materials known allowing the preparation of …