Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Background Post-stroke depression (PSD) is common and associated with higher mortality,
poorer recovery, more pronounced cognitive deficits, and lower quality of life than is stroke …

Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …

Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …

Background: Studies investigating the impact of a variety of inflammatory stimuli on the brain
and behavior have reported evidence that inflammation and release of inflammatory …

Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …

Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Resilience is the process that allows individuals to adapt to adverse conditions and recover
from them. This process is favored by individual qualities that have been amply studied in …