Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …

Infection with the human immunodeficiency virus (HIV) results in a profound
immunosuppression due predominantly to a selective depletion of helper/inducer T …

Infection with human immunodeficiency virus type 1 (HIV-1) is frequently complicated in its
late stages by the AIDS dementia complex, a neurological syndrome characterized by …

Chemokines were originally described as chemotactic cytokines involved in leukocyte
trafficking. Research over the last decade, however, has shown that chemokine receptors …

The AIDS pandemic continues to spread unchecked in many parts of the world, with greater
than 34 million individuals currently infected with human immunodeficiency virus (HIV) …

Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1
(HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect …

HIV-1 replication in the central nervous system (CNS) is typically limited by the availability of
target cells. HIV-1 variants that are transmitted and dominate the early stages of infection …

Previous experiments indicate that the V3 hypervariable region of the human
immunodeficiency virus (HIV) envelope protein influences cell tropism of infection; however …

The blood-brain barrier (BBB) plays a critical role in regulating cell trafficking through the
central nervous system (CNS) due to several unique anatomical features, including the …

Human immunodeficiency virus (HIV) infection of brain macrophages and astroglial
proliferation are central features of HIV-induced central nervous system (CNS) disorders …