Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

Soft contact lenses as drug delivery systems: a review

I Rykowska, I Nowak, R Nowak - Molecules, 2021 - mdpi.com
This review describes the role of contact lenses as an innovative drug delivery system in
treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly …

[HTML][HTML] Mucoadhesive brinzolamide-loaded nanofibers for alternative glaucoma treatment

O Cegielska, M Sierakowski, P Sajkiewicz… - European Journal of …, 2022 - Elsevier
Despite the advances in the field of pharmaceutical materials and technology, topical
administration remains a method of choice for the treatment of eye diseases such as …

Overview of recent advances in nano-based ocular drug delivery

LC Liu, YH Chen, DW Lu - International Journal of Molecular Sciences, 2023 - mdpi.com
Ocular diseases profoundly impact patients' vision and overall quality of life globally.
However, effective ocular drug delivery presents formidable challenges within clinical …

Recent advancements in nanomaterial-laden contact lenses for diagnosis and treatment of glaucoma, review and update

R Baghban, MR Talebnejad, A Meshksar… - Journal of …, 2023 - Springer
Despite the existence of numerous eye drops in the market, most of them are not sufficiently
effective because of quick clearance and the barriers within the eye. To increase the delivery …

Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: advances in extended and targeted drug delivery

B Abdi, M Mofidfar, F Hassanpour, EK Cilingir… - International journal of …, 2023 - Elsevier
The eye is one of the most important organs in the human body providing critical information
on the environment. Many corneal diseases can lead to vision loss affecting the lives of …

Perspectives of molecularly imprinted polymer-based drug delivery systems in ocular therapy

AE Bodoki, BC Iacob, E Dinte, O Vostinaru, O Samoila… - Polymers, 2021 - mdpi.com
Although the human eye is an easily accessible sensory organ, it remains a challenge for
drug administration due to the presence of several anatomical and physiological barriers …

Biomedical potential of hydrogels: a multifaceted approach to innovative medication delivery

S Selvaraj, V Dutta, C Gopalakrishnan… - Emergent …, 2024 - Springer
Hydrogels are 3-dimensional networks synthesized using natural or synthetic polymers with
their ability to retain and transport water. The hydrogels have high permeability …

Synthesis and evaluation of modified lens using plasma treatment containing timolol-maleate loaded lauric acid-decorated chitosan-alginate nanoparticles for …

MS Hosseini, M Mohseni, M Naseripour… - Journal of …, 2023 - Taylor & Francis
Reducing intraocular pressure (IOP) with eye drops is one of the most common ways to
control glaucoma. Low bioavailability and high frequency of administration in eye drops are …

Co-delivery of Brinzolamide and Timolol from Micelles-laden Contact Lenses: In vitro and In Vivo Evaluation

H Yang, F Zhang, Y Fan, J Zhang, T Fang… - Pharmaceutical …, 2024 - Springer
Purpose Traditional eye drops exhibit a modest bioavailability ranging from 1 to 5%,
necessitating recurrent application. Thus, a contact lens-based drug delivery system …