Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement
R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …
RNAi-based therapeutics and tumor targeted delivery in cancer
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …
for the development of targeted therapies for cancer and other diseases. The discovery of …
[HTML][HTML] A comprehensive review of the global efforts on COVID-19 vaccine development
Y Li, R Tenchov, J Smoot, C Liu, S Watkins… - ACS Central …, 2021 - ACS Publications
A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development | ACS
Central Science ACS ACS Publications C&EN CAS Find my institution Log In ACS Central …
Central Science ACS ACS Publications C&EN CAS Find my institution Log In ACS Central …
[HTML][HTML] MicroRNA therapeutics in cancer: current advances and challenges
Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …
[HTML][HTML] Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications
AR Sharma, YH Lee, A Bat-Ulzii… - Journal of …, 2022 - Springer
Recent efforts in designing nanomaterials to deliver potential therapeutics to the targeted
site are overwhelming and palpable. Engineering nanomaterials to deliver biological …
site are overwhelming and palpable. Engineering nanomaterials to deliver biological …
[HTML][HTML] Mechanistic understanding from molecular dynamics simulation in pharmaceutical research 1: drug delivery
In this review, we outline the growing role that molecular dynamics simulation is able to play
as a design tool in drug delivery. We cover both the pharmaceutical and computational …
as a design tool in drug delivery. We cover both the pharmaceutical and computational …
[HTML][HTML] A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion …
K Yang, L Zeng, A Ge, S Wang, J Zeng, X Yuan… - Frontiers in …, 2022 - frontiersin.org
Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest
mortality and disability rate of cardiovascular disease. Current studies have shown that …
mortality and disability rate of cardiovascular disease. Current studies have shown that …
[HTML][HTML] A defective viral genome strategy elicits broad protective immunity against respiratory viruses
RNA viruses generate defective viral genomes (DVGs) that can interfere with replication of
the parental wild-type virus. To examine their therapeutic potential, we created a DVG by …
the parental wild-type virus. To examine their therapeutic potential, we created a DVG by …
Chitosan nanocarriers for microRNA delivery and detection: A preliminary review with emphasis on cancer
In recent years, gene therapy based on miRNA has been employed as a potential growing
technique for treating various co-morbidities. Direct administration of miRNA is unrealistic …
technique for treating various co-morbidities. Direct administration of miRNA is unrealistic …
[HTML][HTML] miRNA delivery by nanosystems: state of the art and perspectives
MicroRNAs (miRNAs) are short (~ 21–23 nucleotides), non-coding endogenous RNA
molecules that modulate gene expression at the post-transcriptional level via the …
molecules that modulate gene expression at the post-transcriptional level via the …