Recent research on cellular mechanisms of peripheral taste has defined transduction
pathways involving membrane receptors, G proteins, second messengers, and ion …

Taste buds are the transducing endorgans of gustation. Each taste bud comprises 50–100
elongated cells, which extend from the basal lamina to the surface of the tongue, where their …

Sensory transduction for many taste stimuli such as sugars, some bitter compounds and
amino acids is thought to be mediated via G protein-coupled receptors (GPCRs), although …

Individuals widely use non-nutritive sweeteners (NNS) in attempts to lower their overall daily
caloric intake, lose weight, and sustain a healthy diet. There are insufficient scientific data …

Taste buds are peripheral chemosensory organs situated in the oral cavity. Each taste bud
consists of a community of 50–100cells that interact synaptically during gustatory …

▪ Abstract Taste receptor cells respond to gustatory stimuli using a complex arrangement of
receptor molecules, signaling cascades, and ion channels. When stimulated, these cells …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

A family of approximately 30 TAS2R bitter taste receptors has been identified in mammals.
Their genes evolved through adaptive diversification and are linked to chromosomal loci …

A vast number of structurally diverse bitter compounds need to be detected by a subfamily of
only approximately 25 human bitter receptors. Failure in detecting them might be lethal …

Sweetness is the preferred taste of humans and many animals, likely because sugars are a
primary source of energy. In many mammals, sweet compounds are sensed in the tongue by …