Although the brain has classically been considered “immune-privileged”, current research
suggests an extensive communication between the immune and nervous systems in both …

The MHC fold is found in proteins that have a range of functions in the maintenance of an
organism's health, from immune regulation to fat metabolism. Well adapted for antigen …

Autism spectrum disorders (ASD) are serious multisystem developmental disorders and an
urgent global public health concern. Dysfunctional immunity and impaired brain function are …

Abstract Background Individuals with 22q11. 2 Deletion Syndrome (22q11. 2 DS) are a
specific high-risk group for developing schizophrenia (SZ), schizoaffective disorder (SAD) …

Nervous system development proceeds by sequential gene expression mediated by
cascades of transcription factors in parallel with sequences of patterned network activity …

Schizophrenia (SCZD) is a heritable developmental disorder. Although the molecular
mechanism of disease remains unclear, insights into the disorder have been made through …

The major histocompatibility complex I (MHCI) pathway, which canonically functions in
innate immune viral antigen presentation and detection, is functionally pleiotropic in the …

Abstract Changes in synapse structure occur in frontal neocortex with HIV encephalitis
(HIVE) and may contribute to HIV-associated neurocognitive disorders (HAND). A …

In the central nervous system, major histocompatibility complex class I (MHCI) molecules are
mainly expressed in neurons, and neuronal MHCI have roles in synapse elimination and …

Schizophrenia (SZ) and autism spectrum disorders (ASD) are highly heritable
neuropsychiatric disorders, although environmental factors, such as maternal immune …