The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila
melanogaster has proven to be a powerful model for the study of innate immunity. Early work …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity of …

Central and peripheral insulin-like peptides (ILPs), which include insulin, insulin-like growth
factor 1 (IGF1) and IGF2, exert many effects in the brain. Through their actions on brain …

Animal lifespan is regulated by conserved metabolic signalling pathways and specific
transcription factors, but whether these pathways affect common downstream mechanisms …

Drosophila melanogaster has been a key model in developing our current understanding of
the molecular mechanisms of ageing. Of particular note is its role in establishing the …